Article
The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity.
Cell - 3 Sept 2020
Li Qianqian, Wu Jiajing, Nie Jianhui, Zhang Li, Hao Huan, Liu Shuo, Zhao Chenyan, Zhang Qi, Liu Huan, Nie Lingling, Qin Haiyang, Wang Meng, Lu Qiong, Li Xiaoyu, Sun Qiyu, Liu Junkai, Zhang Linqi, Li Xuguang, Huang Weijin, Wang Youchun
Abstract excerpt
The spike protein of SARS-CoV-2 has been undergoing mutations and is highly glycosylated. It is critically important to investigate the biological significance of these mutations. Here, we investigated 80 variants and 26 glycosylation site modifications for the infectivity and reactivity to a panel of neutralizing antibodies and sera from convalescent patients. D614G, along with several variants containing both...
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