Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

What can we learn about lipoprotein metabolism and coronary heart disease from studying rare variants?

Current opinion in lipidology - 1 Apr 2016

Jeff Janina M, Peloso Gina M, Do Ron

Abstract excerpt

PURPOSE OF REVIEW: Rare variant association studies (RVAS) target the class of genetic variation with frequencies less than 1%. Recently, investigators have used exome sequencing in RVAS to identify rare alleles responsible for Mendelian diseases but have experienced greater difficulty discovering such alleles for complex diseases. In this review, we describe what we have learned about lipoprotein metabolism and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Coronary Artery Disease
Share to DNA Mutational Analysis
Share to Drug Discovery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Genetic Variation

Share to Genome-Wide Association Study

Share to Lipoproteins

Share to Molecular Targeted Therapy

Source

Open in PubMed Open full text

Identifiers

PMID: 26844526
DOI: 10.1097/MOL.0000000000000277
PMCID: PMC4819247

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

What can we learn about lipoprotein metabolism and coronary heart disease from studying rare variants?PMID 26844526Read ↗

Exome wide association study for blood lipids in 1,158,017 individuals from diverse populationsSemantic proximity Read ↗

JCL roundtable: Lessons from genetic variants altering lipoprotein metabolism.Semantic proximity Read ↗

Exome-wide association study of blood lipids in 1,158,017 individuals from diverse populations.Semantic proximity Read ↗

Insights into blood lipids from rare variant discovery.Semantic proximity Read ↗

Rare and common coding variants in lipid metabolism-related genes and their association with coronary artery disease.Semantic proximity Read ↗

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.Semantic proximity Read ↗

Genetics of Lipid and Lipoprotein Disorders and TraitsSemantic proximity Read ↗

Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank.Semantic proximity Read ↗

Global genetic diversity of human apolipoproteins and effects on cardiovascular disease risk.Semantic proximity Read ↗

Common and Rare Variant Association Study for Plasma Lipids and Coronary Artery Disease.Semantic proximity Read ↗

Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol.Semantic proximity Read ↗

The influence of rare variants in circulating metabolic biomarkersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.