Article

FAK inhibitor treatment systemically regulates the glioblastoma immune environment via blocking monocyte trafficking

2025-12-01

Abstract excerpt

Glioblastoma (GBM) is the most common primary malignant brain tumour in adults with dismal survival rates, and current therapies, including most immunotherapies, are not efficacious due to the highly immunosuppressive microenvironment. Studies in other solid cancers report that impairment of the integrin effector pathway involving focal adhesion kinase (FAK) can promote anti-tumour immune responses. Therefore, we...

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Literature Corpus work: 29eabd07-9074-53ac-93b8-06549559b697
DOI: 10.1101/2025.11.26.690731

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