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Mitochondrial carbonic anhydrase-VB inhibition rescues brain endothelial stress and memory in Alzheimer’s disease models

2026-03-18

Abstract excerpt

Alzheimer’s Disease (AD) is a devastating neurodegenerative disorder with no effective cure, characterized by the cerebral parenchymal and vascular accumulation of aggregated Amyloid-β (Aβ) and hyperphosphorylated tau. Cerebrovascular and mitochondria dysfunction are early causal events in the progression of AD. Previous studies support that inhibiting carbonic anhydrases (CA) may prevent mitochondrial and cerebro...

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Literature Corpus work
29dd68ae-1064-5eb2-a81f-9dc960ae8c9e
DOI
10.64898/2026.03.16.711716
Open publication

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