Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The KATP channel activator diazoxide ameliorates amyloid-β and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2010

Liu Dong, Pitta Michael, Lee Jong-Hwan, Ray Balmiki, Lahiri Debomoy K, Furukawa Katsutoshi, Mughal Mohamed, Jiang Haiyang, Villarreal Julissa, Cutler Roy G, Greig Nigel H, Mattson Mark P

Abstract excerpt

Compromised cellular energy metabolism, cerebral hypoperfusion, and neuronal calcium dysregulation are involved in the pathological process of Alzheimer's disease (AD). ATP-sensitive potassium (KATP) channels in plasma membrane and inner mitochondrial membrane play important roles in modulating n...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diazoxide
Share to Excitatory Amino Acid Agonists

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to KATP Channels

Share to Membrane Potential, Mitochondrial

Share to Memory Disorders

Share to N-Methylaspartate

Share to Potassium Channels, Inwardly Rectifying

Share to Tauopathies

Source

Open in PubMed Open full text

Identifiers

PMID: 20847430
DOI: 10.3233/JAD-2010-101017
PMCID: PMC2988870

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20847430-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The KATP channel activator diazoxide ameliorates amyloid-β and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease.PMID 20847430Read ↗

Thiamine pyrophosphokinase-1 deficiency in neurons drives Alzheimer’s multiple pathophysiological alterationsSemantic proximity Read ↗

Therapeutic Potential of Heterocyclic Compounds Targeting Mitochondrial Calcium Homeostasis and Signaling in Alzheimer’s Disease and Parkinson’s DiseaseSemantic proximity Read ↗

ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction.Semantic proximity Read ↗

Diazoxide/dibenozylmethane treatment mitigates spatial memory deficits and pathology and upregulates protective genes in an Alzheimer’s transgenic rat modelSemantic proximity Read ↗

Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline.Semantic proximity Read ↗

The 40 Hz flickering light restores synaptic plasticity and mitochondrial phenotype in experimental model of Alzheimer’s diseaseSemantic proximity Read ↗

KATP channel mutation disrupts hippocampal network activity and nocturnal gamma shifts.Semantic proximity Read ↗

Levetiracetam Alleviates Cognitive Decline in Alzheimer’s Disease Animal Model by Ameliorating the Dysfunction of the Neuronal NetworkSemantic proximity Read ↗

Decreased accumulation of subcellular amyloid-β with improved mitochondrial function mediates the neuroprotective effect of huperzine A.Semantic proximity Read ↗

Neuronal hyperexcitability in Alzheimer's disease: what are the drivers behind this aberrant phenotype?Semantic proximity Read ↗

Limiting RyR2 Open Time Prevents Alzheimer's Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation.Semantic proximity Read ↗

Age-related impairment of cerebral blood flow response to KATP channel opener in Alzheimer's disease mice with presenilin-1 mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.