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Article

The KATP channel activator diazoxide ameliorates amyloid-β and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2010

Liu Dong, Pitta Michael, Lee Jong-Hwan, Ray Balmiki, Lahiri Debomoy K, Furukawa Katsutoshi, Mughal Mohamed, Jiang Haiyang, Villarreal Julissa, Cutler Roy G, Greig Nigel H, Mattson Mark P

Abstract excerpt

Compromised cellular energy metabolism, cerebral hypoperfusion, and neuronal calcium dysregulation are involved in the pathological process of Alzheimer's disease (AD). ATP-sensitive potassium (KATP) channels in plasma membrane and inner mitochondrial membrane play important roles in modulating neuronal excitability, cell survival, and cerebral vascular tone. To investigate the therapeutic potential of drugs that...

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Identifiers

PMID: 20847430
DOI: 10.3233/JAD-2010-101017
PMCID: PMC2988870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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