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Article

Defining the domains of Cia2 required for its essential function in vivo and in vitro.

Metallomics : integrated biometal science - 15 Nov 2017

Vo Amanda T, Fleischman Nicholas M, Marquez Melissa D, Camire Eric J, Esonwune Stephanie U, Grossman John D, Gay Kelly A, Cosman Jessica A, Perlstein Deborah L

Abstract excerpt

The cytosolic iron-sulfur cluster assembly (CIA) system biosynthesizes iron-sulfur (FeS) cluster cofactors for cytosolic and nuclear proteins. The yeast Cia2 protein is the central component of the targeting complex which identifies apo-protein targets in the final step of the pathway. Herein, we determine that Cia2 contains five conserved motifs distributed between an intrinsically disordered N-terminal domain...

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PMID: 29057997
DOI: 10.1039/c7mt00181a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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