Article

Differential turnover of Nup188 controls its levels at centrosomes and role in centriole duplication

2019-06-10

Abstract excerpt

NUP188 encodes a scaffold component of the nuclear pore complex (NPC) and has been implicated as a congenital heart disease gene through an ill-defined function at centrioles. Here, we explore the mechanisms that physically and functionally segregate Nup188 between the pericentriolar material (PCM) and NPCs throughout the cell cycle. Pulse-chase fluorescent labeling approaches indicate that Nup188 populates centro...

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Literature Corpus work: 29ac8a90-5718-5b3b-a85a-cc20c463185c
DOI: 10.1101/664409

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