Article

The pathogenic mutant vimentin L387P disrupts endoplasmic reticulum organization and proteostasis

2025-12-08

Abstract excerpt

The organization and dynamic regulation of the vimentin intermediate filament network are essential for diverse cellular processes, including cell division, cytoskeletal crosstalk, and organelle positioning. In particular, the vimentin network is required to maintain a compact perinuclear endoplasmic reticulum (ER) that supports the ER quality-control compartment. Here, we show that the vimentin variant c.1160T>C...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d1e6360d-6474-543f-9e26-ccc542432bee
DOI: 10.64898/2025.12.07.692853

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The pathogenic mutant vimentin L387P disrupts endoplasmic reticulum organization and proteostasisDOI 10.64898/2025.12.07.692853Read

A dominant vimentin variant causes a rare syndrome with premature aging.Semantic proximity Read

The VCP/p97 system at a glance: connecting cellular function to disease pathogenesisSemantic proximity Read

Valosin-Containing Protein (VCP): A Review of Its Diverse Molecular Functions and Clinical Phenotypes.Semantic proximity Read

Lamin a truncation in Hutchinson-Gilford progeria.Semantic proximity Read

Induction of a massive endoplasmic reticulum and perinuclear space expansion by expression of lamin B receptor mutants and the related sterol reductases TM7SF2 and DHCR7.Semantic proximity Read

Diseases of the Nucleoskeleton.Semantic proximity Read

Filaments and phenotypes: cellular roles and orphan effects associated with mutations in cytoplasmic intermediate filament proteinsSemantic proximity Read

The E262K mutation in Lamin A links nuclear proteostasis imbalance to laminopathy-associated premature aging.Semantic proximity Read

Lamin A/C, laminopathies and premature ageing.Semantic proximity Read

Deleterious assembly of the lamin A/C mutant p.S143P causes ER stress in familial dilated cardiomyopathy.Semantic proximity Read

The double whammy of ER-retention and dominant-negative effects in numerous autosomal dominant diseases: significance in disease mechanisms and therapy.Semantic proximity Read

Nesprin-2 giant safeguards nuclear envelope architecture in LMNA S143F progeria cells.Semantic proximity Read