Article

Lower peripheral helper T cells in the synovium are associated with a better response to anti-TNF therapy in rheumatoid arthritis

2020-04-09

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>The mechanisms by which only some rheumatoid arthritis (RA) patients respond favorably to TNF blockade are still poorly characterized. The goal of this study was to identify biological features that explain this differential response using a multilevel transcriptome analysis of the synovial membrane.<bold>Methods: </bold>Synovial samples from 11 patients startin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 29a97f68-c118-509d-bb1b-9562c24cb156
DOI: 10.21203/rs.3.rs-21821/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lower peripheral helper T cells in the synovium are associated with a better response to anti-TNF therapy in rheumatoid arthritisDOI 10.21203/rs.3.rs-21821/v1Read

Peripheral blood cellular dynamics of Rheumatoid arthritis treatment informs about efficacy of response to disease modifying drugsSemantic proximity Read

Early Prediction of Clinical Response to Anti-TNF Treatment using Multi-omics and Machine Learning in Rheumatoid ArthritisSemantic proximity Read

Associations between rheumatoid arthritis clinical factors with synovial cell types and statesSemantic proximity Read

Single cell immunoprofile of synovial fluid in rheumatoid arthritis with TNF-α/JAK inhibitor treatmentSemantic proximity Read

Synovial Transcriptome Profiling for Predicting Biological Treatment Response in Rheumatoid Arthritis: A Feasibility studySemantic proximity Read

Disease activity drives transcriptomic heterogeneity in early untreated rheumatoid synovitisSemantic proximity Read

Profiling the peripheral immune response to ex vivo TNF stimulation in untreated juvenile idiopathic arthritis using single cell RNA sequencing.Semantic proximity Read

Monocyte-derived transcriptomes explain the ineffectiveness of abatacept in rheumatoid arthritisSemantic proximity Read

Immunomics analysis of rheumatoid arthritis identified precursor dendritic cells as a key cell subset of treatment resistanceSemantic proximity Read

RA and PsA synovial tissue single-cell analysis demonstrates differential fibroblast populations with distinct phenotypes and functional capacities.Semantic proximity Read

Persistent circulating autoreactive PD1⁺TIGIT⁺ peripheral helper T cells reflect synovial lymphoid activity and poor response to conventional disease-modifying anti-rheumatic drugs in early rheumatoid arthritisSemantic proximity Read

Vascular synovial phenotype indicates poor response to JAK inhibitors in rheumatoid arthritis patients: a pilot study.Semantic proximity Read