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Article

RA and PsA synovial tissue single-cell analysis demonstrates differential fibroblast populations with distinct phenotypes and functional capacities.

Annals of the rheumatic diseases - 1 Aug 2026

Tynan Órla, Brugman Aenea A I, Smith Conor M, Canavan Mary, O'Rourke Aoife M, Floudas Achilleas, Anton Dumitru, Wade Siobhán, Sundanum Sonia, Fletcher Jean M, Orr Carl, Veale Douglas J, Fearon Ursula

Abstract excerpt

OBJECTIVES: This study determines the phenotypic and functional characteristics that define distinct fibroblast-like synoviocyte (FLS) populations in rheumatoid arthritis (RA) vs psoriatic arthritis (PsA). METHODS: Single-cell RNA sequencing and multiparametric flow cytometry analysis (21 markers) were performed on RA and PsA synovial cell suspensions to determine FLS phenotype/function. Podoplanin (PDPN)+ FLS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41966860
DOI: 10.1016/j.ard.2026.03.010

Genes

THY1
CD55
FAP
CD34
CD44
PDPN
APOE
CHI3L2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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