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Monocyte-derived transcriptomes explain the ineffectiveness of abatacept in rheumatoid arthritis

2 Jan 2024

Abstract excerpt

BACKGROUND: The biological mechanisms underlying the differential response to abatacept in patients with rheumatoid arthritis (RA) are unknown. Here, we aimed to identify cellular, transcriptomic, and proteomic features that predict resistance to abatacept in patients with RA. METHODS: Blood samples were collected from 22 RA patients treated with abatacept at baseline and after 3 months of treatment. Response to...

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PMID: 38167328
DOI: 10.1186/s13075-023-03236-y

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