Article

Peripheral <i>Htt</i> silencing does not ameliorate central signs of disease in the B6. <i> Htt <sup>Q111/+</sup> </i> mouse model of Huntington’s Disease

2016-12-29

Abstract excerpt

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease whose neuropathological signature is a selective loss of medium spiny neurons in the striatum. Despite this selective neuropathology, the mutant protein (huntingtin) is found in virtually every cell so far studied, and, consequently, phenotypes are observed in a wide range of organ systems both inside and outside the central nervous syste...

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Literature Corpus work: 278fef1d-f194-52b9-9393-f1364b6b6ab0
DOI: 10.1101/096990

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