Article

Variant-specific humoral immune response to SARS-CoV-2 escape mutants arising in clinically severe, prolonged infection

2024-01-07

Abstract excerpt

Neutralising antibodies against the SARS-CoV-2 spike (S) protein are major determinants of protective immunity, though insufficient antibody responses may cause the emergence of escape mutants. We studied the intra-host evolution and the humoral immune response in a B-cell depleted, haemato-oncologic patient experiencing clinically severe, prolonged SARS-CoV-2 infection with a virus of lineage B.1.177.81. Bamlaniv...

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Literature Corpus work: 29625bd0-d4b0-53dd-a24f-aee7e63ae004
DOI: 10.1101/2024.01.06.24300890

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