Article

Longitudinal Analysis of Escape Mutations in SARS-CoV-2 Omicron Variants after Sotrovimab Use in Immunodeficient Patients

2022-06-14

Abstract excerpt

Background: Monoclonal antibodies (mAb) targeting SARS-CoV-2 are predominantly less effective against Omicron variants. Immunocompromised patients often experience prolonged viral shedding and are therefore at increased risk for viral escape mutations, when mAbs are used as monotherapy.<br><br>Methods: In an observational, prospective cohort, 57 patients infected with Omicron variants receiving sotrovimab alone or...

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Literature Corpus work: 4c787bea-93ee-5f1e-abb8-5eec5b79bb66
DOI: 10.2139/ssrn.4136279

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