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Article

Emergence of SARS-CoV-2 escape mutations during Bamlanivimab therapy in a phase II randomized clinical trial.

Nature microbiology - 1 Nov 2022

Choudhary Manish C, Chew Kara W, Deo Rinki, Flynn James P, Regan James, Crain Charles R, Moser Carlee, Hughes Michael D, Ritz Justin, Ribeiro Ruy M, Ke Ruian, Dragavon Joan A, Javan Arzhang Cyrus, Nirula Ajay, Klekotka Paul, Greninger Alexander L, Fletcher Courtney V, Daar Eric S, Wohl David A, Eron Joseph J, Currier Judith S, Parikh Urvi M, Sieg Scott F, Perelson Alan S, Coombs Robert W, Smith Davey M, Li Jonathan Z

Abstract excerpt

SARS-CoV-2 mutations that cause resistance to monoclonal antibody (mAb) therapy have been reported. However, it remains unclear whether in vivo emergence of SARS-CoV-2 resistance mutations alters viral replication dynamics or therapeutic efficacy in the immune-competent population. As part of the ACTIV-2/A5401 randomized clinical trial (NCT04518410), non-hospitalized participants with symptomatic SARS-CoV-2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36289399
DOI: 10.1038/s41564-022-01254-1
PMCID: PMC9675946

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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