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Article

Characterisation of the antibody-mediated selective pressure driving intra-host evolution of SARS-CoV-2 in prolonged infection.

PLoS pathogens - 1 Oct 2024

Schoefbaenker Michael, Günther Theresa, Lorentzen Eva Ulla, Romberg Marie-Luise, Hennies Marc Tim, Neddermeyer Rieke, Müller Marlin Maybrit, Mellmann Alexander, Bojarzyn Chiara Robin, Lenz Georg, Stelljes Matthias, Hrincius Eike Roman, Vollenberg Richard, Ludwig Stephan, Tepasse Phil-Robin, Kühn Joachim Ewald

Abstract excerpt

Neutralising antibodies against the SARS-CoV-2 spike (S) protein are major determinants of protective immunity, though insufficient antibody responses may cause the emergence of escape mutants. We studied the humoral immune response causing intra-host evolution in a B-cell depleted, haemato-oncologic patient experiencing clinically severe, prolonged SARS-CoV-2 infection with a virus of lineage B.1.177.81....

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Share to Antibodies, Monoclonal, Humanized
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39405332
DOI: 10.1371/journal.ppat.1012624
PMCID: PMC11508484

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