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Vitamin B12 attenuates leukocyte inflammatory signature in COVID-19 via methyl-dependent changes in epigenetic marks

2022-08-09

Abstract excerpt

COVID-19 induces chromatin remodeling in host immune cells, and it had previously been shown that vitamin B12 downregulates some inflammatory genes via methyl-dependent epigenetic mechanisms. In this work, whole blood cultures from moderate or severe COVID-19 patients were used to assess the potential of B12 as adjuvant drug. The vitamin normalized the expression of a panel of inflammatory genes still dysregulated...

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Literature Corpus work
ca4a15ee-d81e-5b6d-a8db-fe28c5d5ef75
DOI
10.1101/2022.08.08.503231
Open publication

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Vitamin B12 attenuates leukocyte inflammatory signature in COVID-19 via methyl-dependent changes in epigenetic marksDOI 10.1101/2022.08.08.503231
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