Article

Mupirocin Blocks Imiquimod-induced Psoriasis-like skin Lesion by Inhibiting Epidermal Isoleucyl-tRNA Synthetase

2022-08-10

Abstract excerpt

<h4>Background: </h4> The Isoleucyl-tRNA synthetase (IARS) catalyzes isoleucine to the corresponding tRNA, maintaining the accuracy of gene translation. Its role in psoriasis has been not investigated so far. In this study, we aimed to investigate the mechanisms underlying the efficacy of IARS inhibitor, mupirocin, treatment for psoriasis. <h4>Methods: </h4>: The expression of IARS was determined by immunofluoresc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2947139a-77b2-5b5b-a903-9f9736610153
DOI: 10.21203/rs.3.rs-1941380/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mupirocin Blocks Imiquimod-induced Psoriasis-like skin Lesion by Inhibiting Epidermal Isoleucyl-tRNA SynthetaseDOI 10.21203/rs.3.rs-1941380/v1Read

Allicin Ameliorates IMQ-induced psoriasis-like Skin Inflammation Via Disturbing the Interaction of Keratinocytes with IL-17ASemantic proximity Read

Various applications of microRNAs in skin diseasesSemantic proximity Read

Aminoacyl-tRNA synthetases in medicine and disease.Semantic proximity Read

Inhibition of eukaryotic translation initiation factor 1A (eIF1A) and 3B (eIF3B) diminishes the psoriatic phenotype in two mouse models and human 3D model samplesSemantic proximity Read

Recent Development of Aminoacyl-tRNA Synthetase Inhibitors for Human Diseases: A Future PerspectiveSemantic proximity Read

Molecular screening for nigericin treatment in pancreatic cancer by high-throughput RNA sequencingSemantic proximity Read

Tanshinone I Ameliorates Psoriasis-Like Dermatitis by Suppressing Inflammation and Regulating Keratinocyte DifferentiationSemantic proximity Read

Inhibition of eukaryotic translation initiation factor 1 A (eIF1A) and 3B (eIF3B) diminishes the psoriatic phenotype in two mouse models and human 3D model samples.Semantic proximity Read

Comparative analysis of the transcriptome and efficacy of bioactive Centella asiatica exosomes on skin cellsSemantic proximity Read

Effects of splenectomy on skin inflammation and psoriasis-like phenotype of imiquimod-treated mice.Semantic proximity Read

Activation of unfolded protein response pathways promotes keratinocyte differentiation and ameliorates psoriasis phenotypes.Semantic proximity Read

Exosome-like nanovesicles derived from Phellinus linteus inhibit Mical2 expression through cross-kingdom regulation and inhibit ultraviolet-induced skin agingSemantic proximity Read