Article

Mechanism of αO-Conotoxin GeXIVA[1,2], a Novel Nonaddictive Analgesic, Based on In Vivo Disposition and Modelling

2022-04-05

Abstract excerpt

<h4>Background: </h4> and purpose: αO-conotoxin GeXIVA[1,2], a natural peptide discovered by our laboratory from Conus generalis in the South China Sea, is a novel nonaddictive analgesic targeting the α9α10 nicotinic acetylcholine receptor (nAChR). This study aimed to elucidate the underlying mechanisms by the disposition and modelling of GeXIVA[1,2]. Experimental approach: The pharmacokinetics (PK) of GeXIVA[1,2]...

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Literature Corpus work: 98f638bd-887e-534e-b490-6ae90b6d9506
DOI: 10.22541/au.164917273.36767334/v1

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