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Article

Contribution of oxycodone and its metabolites to the overall analgesic effect after oxycodone administration.

Expert opinion on drug metabolism & toxicology - 1 May 2013

Klimas Romina, Witticke Diana, El Fallah Sarah, Mikus Gerd

Abstract excerpt

OBJECTIVE: Oxycodone (OC) is an opioid which exerts its analgesic effect through µ-receptors in the brain. It is metabolized through CYP450 enzymes and some of the metabolites show pharmacological activity. The aim of this investigation is to research the contribution of the metabolites of OC to its overall analgesic effect. A further aim was to elucidate the role of drug-drug interactions and CYP2D6...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23488585
DOI: 10.1517/17425255.2013.779669

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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