Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Countrywide Survey of hrp2/3 Deletions and kelch13 Mutations Co-occurrence in Ethiopia.

The Journal of infectious diseases - 16 Dec 2024

Kamaliddin Claire, Burke-Gaffney Jack, Ashraf Shoaib, Castañeda-Mogollón Daniel, Adamu Aderaw, Mekonen Tefa Bacha, Wijesinghe Ayesha, Pussegoda Enaara, Feleke Sindew Mekasha, Pillai Dylan R

Abstract excerpt

Malaria elimination relies on detection of Plasmodium falciparum histidine-rich proteins 2/3 (HRP2/3) through rapid diagnostic tests (RDTs) and treatment with artemisinin combination therapies (ACTs). Data from the Horn of Africa suggest increasing hrp2/3 gene deletions and ACT partial resistance kelch13 (k13) mutations. To assess this, 233 samples collected during a national survey from 7 regions of Ethiopia...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Protozoan
Share to Antimalarials

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Artemisinins

Share to Drug Resistance

Share to Ethiopia

Share to Malaria, Falciparum

Share to Plasmodium falciparum

Share to Protozoan Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 39083679
DOI: 10.1093/infdis/jiae373
PMCID: PMC11646589

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Countrywide Survey of hrp2/3 Deletions and kelch13 Mutations Co-occurrence in Ethiopia.PMID 39083679Read ↗

High prevalence and emerging positive association of kelch13 R622I and HRP2-based RDT negativity in Plasmodium falciparum in northern Ethiopia.Semantic proximity Read ↗

Artemisinin resistant <i>kelch13</i> R622I and RDT negativity approaching predominance in northern Ethiopia and emerging C580Y of African origin threaten falciparum malaria controlSemantic proximity Read ↗

Extensive Deletion and Sequence Variation of Plasmodium Falciparum Histidine Rich Protein 2/3 (pfhrp2/3) Genes in Ethiopia: Implication for RDT-based Malaria Diagnosis and ControlSemantic proximity Read ↗

Emergence and evolution of <i>Plasmodium falciparum</i> histidine-rich protein 2 and 3 deletion mutant parasites in EthiopiaSemantic proximity Read ↗

Detection of high prevalence of Plasmodium falciparum histidine-rich protein 2/3 gene deletions in Assosa zone, Ethiopia: implication for malaria diagnosisSemantic proximity Read ↗

High prevalence and extended deletions in Plasmodium falciparum hrp2/3 genomic loci in EthiopiaSemantic proximity Read ↗

Plasmodium falciparum resistant to artemisinin and diagnostics have emerged in EthiopiaSemantic proximity Read ↗

High-throughput Plasmodium falciparum hrp2 and hrp3 gene deletion typing by digital PCR to monitor malaria rapid diagnostic test efficacySemantic proximity Read ↗

Plasmodium falciparum is evolving to escape malaria rapid diagnostic tests in Ethiopia.Semantic proximity Read ↗

Clonal spread of<i>Plasmodium falciparum</i>candidate artemisinin partial resistance<i>Kelch13</i>622I mutation and co-occurrence with<i>pfhrp2/3</i>deletions in EthiopiaSemantic proximity Read ↗

<i>Plasmodium falciparum hrp2</i> and <i>hrp3</i> gene deletion status in Africa and South America by highly sensitive and specific digital PCRSemantic proximity Read ↗

Deletion of target gene (histidine-rich protein 2/3) for Plasmodium falciparum rapid diagnostic tests in Amhara region, Ethiopia: a cross-sectional studySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.