Article
High prevalence and emerging positive association of kelch13 R622I and HRP2-based RDT negativity in Plasmodium falciparum in northern Ethiopia.
PLoS pathogens - 1 Dec 2025
Zeleke Ayalew Jejaw, Fola Abebe A, Tollefson George A, Niaré Karamako, Leonetti Alec, Taropawala Om, Marglous Jacob, Crudale Rebecca, Brhane Bokretsion G, Assefa Ashenafi, Kiyuka Patience, Parr Jonathan B, Hailu Asrat, Tegegne Mulugeta Aemero, Bailey Jeffrey A
Abstract excerpt
The rise of antimalarial drug-resistant Plasmodium falciparum threatens malaria elimination efforts. Mutations in the gene kelch13 (k13) confer artemisinin partial resistance (ART-R), compromising the efficacy of frontline artemisinin-based combination therapies (ACTs). The validated mutation k13 R622I has emerged and expanded rapidly in the Horn of Africa. We conducted a year-long genomic surveillance study in...
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