Article

Coronavirus Spike-RBD Variants Differentially Bind to the Human ACE2 Receptor

2024-03-08

Abstract excerpt

The SARS-CoV-2 betacoronavirus infects people through binding the human Angiotensin Receptor 2 (ACE2), followed by import into a cell utilizing the Transmembrane Protease, Serine 2 (TMPRSS2) and Furin cofactors. Analysis of the SARS-CoV-2 extracellular spike protein has suggested critical amino acids necessary for binding within a 197-residue portion, the receptor binding domain (RBD). A cell-based assay between a...

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Literature Corpus work: 289478c9-0a32-5607-99c3-3e5700bbe246
DOI: 10.1101/2024.03.07.583944

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