Article

Natural and laboratory mutations in <i>kuzbanian</i> are associated with heavy metal stress phenotypes in <i>Drosophila melanogaster</i>

2016-08-18

Abstract excerpt

<h4>ABSTRACT</h4> Organisms must cope with altered environmental conditions such as high concentrations of heavy metals. Stress response to heavy metals is mediated by the metal-responsive transcription factor 1 (MTF-1), which is conserved from Drosophila to humans. MTF-1 binds to metal response elements (MREs) and changes the expression of target genes. kuzbanian (kuz) , a metalloendopeptidase that activates th...

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Literature Corpus work: 286ed121-9f65-5de2-8755-8f97914cac33
DOI: 10.1101/070243

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