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Article

The four members of the Drosophila metallothionein family exhibit distinct yet overlapping roles in heavy metal homeostasis and detoxification.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jun 2006

Egli Dieter, Domènech Jordi, Selvaraj Anand, Balamurugan Kuppusamy, Hua Haiqing, Capdevila Mercè, Georgiev Oleg, Schaffner Walter, Atrian Sílvia

Abstract excerpt

Four metallothionein genes are present in the Drosophila melanogaster genome, designated MtnA, MtnB, MtnC, MtnD, all of which are transcriptionally induced by heavy metals through the same metal-responsive transcription factor, MTF-1. Here we show, by targeted mutagenesis, that the four metallothionein genes exhibit distinct, yet overlapping, roles in heavy metal homeostasis and toxicity prevention. Among the...

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PMID: 16716195
DOI: 10.1111/j.1365-2443.2006.00971.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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