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Article

Natural and laboratory mutations in kuzbanian are associated with zinc stress phenotypes in Drosophila melanogaster.

Scientific reports - 20 Feb 2017

Le Manh Hung, Guio Lain, Merenciano Miriam, Rovira Quirze, Barrón Maite G, González Josefa

Abstract excerpt

Organisms must cope with altered environmental conditions such as high concentrations of heavy metals. Stress response to heavy metals is mediated by the metal-responsive transcription factor 1 (MTF-1), which is conserved from Drosophila to humans. MTF-1 binds to metal response elements (MREs) and changes the expression of target genes. kuzbanian (kuz), a metalloendopeptidase that activates the evolutionary...

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Identifiers

PMID: 28218276
DOI: 10.1038/srep42663
PMCID: PMC5316978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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