Transcriptome response to heavy metal stress in Drosophila reveals a new zinc transporter that confers resistance to zinc.

doi:10.1093/nar/gkl606

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Article

Transcriptome response to heavy metal stress in Drosophila reveals a new zinc transporter that confers resistance to zinc.

Nucleic acids research - 1 Jan 2006

Yepiskoposyan Hasmik, Egli Dieter, Fergestad Tim, Selvaraj Anand, Treiber Carina, Multhaup Gerd, Georgiev Oleg, Schaffner Walter

Abstract excerpt

All organisms are confronted with external variations in trace element abundance. To elucidate the mechanisms that maintain metal homeostasis and protect against heavy metal stress, we have determined the transcriptome responses in Drosophila to sublethal doses of cadmium, zinc, copper, as well as to copper depletion. Furthermore, we analyzed the transcriptome of a metal-responsive transcription factor (MTF-1)...

Topics

ATP-Binding Cassette Transporters
Animals
Cadmium
Cation Transport Proteins
Copper
DNA-Binding Proteins
Drosophila Proteins
Drosophila melanogaster
Drug Resistance
Ferritins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Profiling

Genome, Insect

Male

Metals, Heavy

Mutation

Oligonucleotide Array Sequence Analysis

Response Elements

Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 16973896
DOI: 10.1093/nar/gkl606
PMCID: PMC1635269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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