Article

Conserved Cell-Type-Specific Transcriptomic Networks and Regulatory Programs Underlie Alcohol Dependence Across Mouse and Human

2026-04-21

Abstract excerpt

<title>Abstract</title> <p>Alcohol use disorder (AUD) is a complex polygenic disease. Rodent models of alcohol dependence have been instrumental in modeling various aspects of dependence. Single-nucleus transcriptomics has enabled the profiling of cell-type-specific changes in gene expression in both human AUD and animal models. In this study, we identified shared dysregulated transcriptomic networks (TN), compri...

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Literature Corpus work: a2cfc132-7249-5e06-a8d7-0719345d721c
DOI: 10.21203/rs.3.rs-9417955/v1

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