Article
Advancing substance use disorder biology by studying underlying gene x environment interactions.
Current opinion in genetics & development - 1 Apr 2026
Sidamon-Eristoff Anne Elizabeth, Rivera-Hernandez Melody, Huckins Laura M, Montalvo-Ortiz Janitza L, Brennand Kristen J
Abstract excerpt
Substance use disorders (SUDs) are heritable, complex genetic disorders associated with a growing list of genetic variants that are common in the population at large. These variants occur in noncoding genomic regions and are presumed to confer risk by altering the expression of one or more target genes; yet, by definition, SUD cannot occur without repeated exposures to drugs, cannabis, or alcohol. Moreover, there...
Topics
- Humans
- Gene-Environment Interaction
- Substance-Related Disorders
- Animals
- Genetic Predisposition to Disease
- Disease Models, Animal