Article

Coevolution of retroviruses with <i>SERINC</i> s following whole-genome duplication divergence

2020-02-24

Abstract excerpt

The SERINC gene family comprises of five paralogs in humans of which SERINC3 and SERINC5 inhibit HIV-1 infectivity and are counteracted by Nef. The origin of this anti-retroviral activity, its prevalence among the remaining paralogs, and its ability to target retroviruses remain largely unknown. Here we show that despite their early divergence, the anti-retroviral activity is functionally conserved among four h...

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Literature Corpus work: 280cc5e3-c63f-5714-b199-38fe71457527
DOI: 10.1101/2020.02.24.962506

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