Article

Glucocorticoid signaling regulates expression of the EBI3 subunit of IL-27 in neonatal macrophages: Implications for antenatal corticosteroid therapy

2026-03-26

Abstract excerpt

<h4>Background</h4> Humans and mice display elevated levels of IL-27, an immunosuppressive cytokine shown to increase during neonatal bacterial sepsis and compromise survival. This study explores two hypotheses for regulation of IL-27 expression: 1) decreased DNA methylation in newborns that contributes to increased expression of IL-27 genes; 2) neonatal hormones regulate IL-27 expression through upstream hormone...

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Literature Corpus work: 27f7de92-b4f5-5746-a6b2-8923b9c374a1
DOI: 10.64898/2026.03.24.713718

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