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Article

Alteration of the brain methylation landscape following postnatal inflammatory injury in rat pups

22 Nov 2019

Abstract excerpt

Preterm infants are vulnerable to inflammation-induced white matter injury (WMI), which is associated with neurocognitive impairment and increased risk of neuropsychiatric diseases in adulthood. Epigenetic mechanisms, particularly DNA methylation, play a role in normal development and modulate the response to pathological challenges. Our aims were to determine how WMI triggered DNA methylation alterations in...

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PMID: 31914673
DOI: 10.1096/fj.201901461r

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