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Article

Effect of dexamethasone on B7 regulation and T cell activation in neonates and adults.

Pediatric research - 1 May 2005

Orlikowsky Thorsten W, Dannecker Günther E, Spring Bärbel, Eichner Martin, Hoffmann Michael K, Poets Christian F

Abstract excerpt

The safety of dexamethasone for neonates has been questioned, partly because of its multiple unspecific effects on the immune system. Specific effects of dexamethasone on co-stimulatory and immune suppressive functions of neonatal compared with adult macrophages (MPhi) are not known. We evaluated the effect of dexamethasone on the expression and regulation of MPhi B7 family receptors (B7-1, CD80; B7-2, CD86) and...

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Identifiers

PMID: 15718366
DOI: 10.1203/01.PDR.0000156211.48307.F5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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