Article

Human-genome gut-microbiome interaction in Parkinson’s disease

2021-01-22

Abstract excerpt

The causes of complex diseases remain an enigma despite decades of epidemiologic research on environmental risks and genome-wide studies that have uncovered tens or hundreds of susceptibility loci for each disease. We hypothesize that the microbiome is the missing link. Genetic studies have shown that overexpression of alpha-synuclein, a key pathological protein in Parkinson’s disease (PD), can cause familial PD a...

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Literature Corpus work: ade152fe-e8ac-5366-afe3-f0889dcb0db6
DOI: 10.1101/2021.01.21.427679

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