Article

Functional Metagenomic Analysis Reveals Early Gut Microbiota Alterations in Alpha-Synuclein Transgenic Mice: Insights into Parkinson’s Disease Progression

2025-03-19

Abstract excerpt

Parkinson’s Disease (PD) is the fastest growing neurodegenerative disease and manifests as a synucleinopathy with progressive motor and non-motor symptoms. In this study, we investigated the gut-microbial alterations associated with PD in an α-synuclein transgenic mouse model (hα-Syn) at both early and late stages of the disease. We utilised high-resolution functional metagenomics with ultra-deep sequencing to ens...

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Literature Corpus work: 0c0931ca-1ee5-59a5-8298-da5d778c1052
DOI: 10.1101/2025.03.18.644066

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