Article
A microbiome quantitative trait locus in SLC39A8 modulates disease severity in synucleinopathy-induced models of Parkinson's disease.
Human molecular genetics - 23 Mar 2026
Yang Julianne C, Situ Jamilla, Troutman Ryan, Zhu Ruowei, Black Margaret, Buri Heidi, Gutta Arjun, Tian Fengrui, Kang Allyson, Aja Ezinne, Zeng Amber, Lai Rochelle W, Tan Jia, Liang Fengting, Brahim Caitlyn, Murphy Grace, Ahdoot Aaron, Peng Chao, Jacobs Jonathan P
Abstract excerpt
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor deficits, dopaminergic neuron loss, and α-synuclein (α-syn) aggregation. While rare mutations underlie familial PD, around 85% of cases are idiopathic. Emerging evidence implicates common genetic variants and the gut microbiome in PD risk, but their interaction has not been studied. We previously demonstrated that the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.