Article

IS-Seq: a bioinformatics pipeline for integration sites analysis with comprehensive abundance quantification methods

2023-02-07

Abstract excerpt

Integration site (IS) analysis is a fundamental analytical platform for evaluating the safety and efficacy of viral vector based preclinical and clinical Gene Therapy (GT). A handful of groups have developed standardized bioinformatics pipelines to process IS sequencing data, to generate reports, and/or to perform comparative studies across different GT trials. Keeping up with the technological advances in the fie...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 27cb9bd0-4962-5eea-bba7-cccd2d478fd8
DOI: 10.1101/2023.02.06.527381

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

IS-Seq: a bioinformatics pipeline for integration sites analysis with comprehensive abundance quantification methodsDOI 10.1101/2023.02.06.527381Read

GENE-IS: Time-Efficient and Accurate Analysis of Viral Integration Events in Large-Scale Gene Therapy DataSemantic proximity Read

Integration Site Analysis in Gene Therapy Patients: Expectations and RealitySemantic proximity Read

Genome-wide profiling of retroviral DNA integration and its effect on clinical pre-infusion CAR T-cell productsSemantic proximity Read

Amplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration SitesSemantic proximity Read

Amplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration SitesSemantic proximity Read

ISAnalytics enables longitudinal and high-throughput clonal tracking studies in hematopoietic stem cell gene therapy applicationsSemantic proximity Read

An analytical pipeline for identifying and mapping the integration sites of HIV and other retrovirusesSemantic proximity Read

LISA: A Comprehensive R Package for Lentiviral Integration Site Analysis in Gene Therapy Safety AssessmentSemantic proximity Read

INSPIIRED: Quantification and Visualization Tools for Analyzing Integration Site DistributionsSemantic proximity Read

High-Throughput Sequencing Reveals Principles of Adeno-Associated Virus Serotype 2 IntegrationSemantic proximity Read

VISDB: a manually curated database of viral integration sites in the human genomeSemantic proximity Read

Analysis of polyclonal vector integration sites using Nanopore sequencing as a scalable, cost-effective platformSemantic proximity Read