Car-γδ T Cells Targeting Claudin18.2 Show Superior Cytotoxicity Against Solid Tumor Compared to Traditional Car-αβ T Cells

Abstract excerpt

<h4>Background: </h4> Claudin18.2 (CLDN18.2) is highly expressed during the development of various malignant tumors, especially gastric cancer, and CAR-T cell targeting CLDN18.2 have therapeutic potential. However, their dependence on the major histocompatibility complex (MHC) for antigen recognition limits their application. Human Gamma Delta (γδ) T cells, with strong MHC-independent cytotoxicity to most solid tu...

Topics

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• Barrier Structure and Function Studies
• Cancer Immunotherapy and Biomarkers
• CAR-T cell therapy research
• Chronic Lymphocytic Leukemia Research
• Colorectal Cancer Treatments and Studies
• Glycosylation and Glycoproteins Research
• Monoclonal and Polyclonal Antibodies Research
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

cce3ab22-827d-5aa7-8a45-12f4bf71ef58

DOI

10.20944/preprints202502.0578.v1