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Article

Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin.

The EMBO journal - 21 Sept 2005

Guo Qing, Shen Yuequan, Lee Young-Sam, Gibbs Craig S, Mrksich Milan, Tang Wei-Jen

Abstract excerpt

CyaA is crucial for colonization by Bordetella pertussis, the etiologic agent of whooping cough. Here we report crystal structures of the adenylyl cyclase domain (ACD) of CyaA with the C-terminal domain of calmodulin. Four discrete regions of CyaA bind calcium-loaded calmodulin with a large buried contact surface. Of those, a tryptophan residue (W242) at an alpha-helix of CyaA makes extensive contacts with the...

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Identifiers

PMID: 16138079
DOI: 10.1038/sj.emboj.7600800
PMCID: PMC1224690

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ACD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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