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Article

Interactions of Bordetella pertussis adenylyl cyclase toxin CyaA with calmodulin mutants and calmodulin antagonists: comparison with membranous adenylyl cyclase I.

Biochemical pharmacology - 1 Apr 2012

Schuler Dominik, Lübker Carolin, Lushington Gerald H, Tang Wei-Jen, Shen Yuequan, Richter Mark, Seifert Roland

Abstract excerpt

The adenylyl cyclase (AC) toxin CyaA from Bordetella pertussis constitutes an important virulence factor for the pathogenesis of whooping cough. CyaA is activated by calmodulin (CaM) and compromises host defense by excessive cAMP production. Hence, pharmacological modulation of the CyaA/CaM interaction could constitute a promising approach to treat whooping cough, provided that interactions of endogenous effector...

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Identifiers

PMID: 22265637
DOI: 10.1016/j.bcp.2012.01.005
PMCID: PMC3915356

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Source receipt: pubmed, retrieved 7 Sept 2026.

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