Article
Identification and evaluation of novel acetolactate synthase inhibitors as antifungal agents.
Antimicrobial agents and chemotherapy - 1 May 2013
Richie Daryl L, Thompson Katherine V, Studer Christian, Prindle Vivian C, Aust Thomas, Riedl Ralph, Estoppey David, Tao Jianshi, Sexton Jessica A, Zabawa Thomas, Drumm Joseph, Cotesta Simona, Eichenberger Jürg, Schuierer Sven, Hartmann Nicole, Movva N Rao, Tallarico John A, Ryder Neil S, Hoepfner Dominic
Abstract excerpt
High-throughput phenotypic screening against the yeast Saccharomyces cerevisiae revealed a series of triazolopyrimidine-sulfonamide compounds with broad-spectrum antifungal activity, no significant cytotoxicity, and low protein binding. To elucidate the target of this series, we have applied a chemogenomic profiling approach using the S. cerevisiae deletion collection. All compounds of the series yielded highly...
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