Article
Genomic mining for Aspergillus natural products.
Chemistry & biology - 1 Jan 2006
Bok Jin Woo, Hoffmeister Dirk, Maggio-Hall Lori A, Murillo Renato, Glasner Jeremy D, Keller Nancy P
Abstract excerpt
The genus Aspergillus is renowned for its ability to produce a myriad of bioactive secondary metabolites. Although the propensity of biosynthetic genes to form contiguous clusters greatly facilitates assignment of putative secondary metabolite genes in the completed Aspergillus genomes, such analysis cannot predict gene expression and, ultimately, product formation. To circumvent this deficiency, we have examined...
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