Article

SEQURNA enhances FLASH-seq gene detection while eliminating DTT dependence

2025-12-15

Abstract excerpt

Effective RNase inhibition is critical for single-cell RNA-sequencing, yet commercial recombinant RNase inhibitors (RRIs) require reducing agents for stability and impose substantial costs. Here, we systematically benchmark SEQURNA, a synthetic thermostable RNase inhibitor, against commercial alternatives using FLASH-seq in human retinal organoids and peripheral blood mononuclear cells (PBMCs). SEQURNA at 0.5–1 U/...

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Literature Corpus work: 26efb960-31a4-57f8-9781-b36543b2ae7b
DOI: 10.64898/2025.12.12.693841

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