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Article

Deciphering the Complexity of MEK Mutations in the Clinic.

Cancer research - 1 Oct 2020

Whitehead Christopher E, Sebolt-Leopold Judith S

Abstract excerpt

Significant advances in tumor sequencing have led to an explosion in our knowledge of the genetic complexity of cancer. For many cancers, the selection of a targetable alteration is not readily apparent, especially when confronted with mutational variants of unknown significance. The complex clinical landscape of MEK mutations illustrates the need for improved methods to identify those patients, independent of...

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PMID: 33008803
DOI: 10.1158/0008-5472.CAN-20-2611

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