Article

PathFinder: a novel graph transformer model to infer multi-cell intra- and inter-cellular signaling pathways and communications

2024-01-15

Abstract excerpt

Recently, large-scale scRNA-seq datasets have been generated to understand the complex and poorly understood signaling mechanisms within microenvironment of Alzheimer’s Disease (AD), which are critical for identifying novel therapeutic targets and precision medicine. Though a set of targets have been identified, however, it remains a challenging to infer the core intra- and inter-multi-cell signaling communication...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 26cf5737-9eb4-5340-ba1c-99c68aa1fcb5
DOI: 10.1101/2024.01.13.575534

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PathFinder: a novel graph transformer model to infer multi-cell intra- and inter-cellular signaling pathways and communicationsDOI 10.1101/2024.01.13.575534Read

scHumanNet: a single-cell network analysis platform for the study of cell-type specificity of disease genesSemantic proximity Read

Decoding cell-type-specific alterations in Alzheimer’s disease through scRNA-seq and network analysisSemantic proximity Read

Single-Cell Transcriptomics Unveils Gene Regulatory Network PlasticitySemantic proximity Read

Knowledge-graph-based cell-cell communication inference for spatially resolved transcriptomic data with SpaTalkSemantic proximity Read

Single-cell network biology characterizes cell type gene regulation for drug repurposing and phenotype prediction in Alzheimer’s diseaseSemantic proximity Read

Single-cell network biology characterizes cell type gene regulation for drug repurposing and phenotype prediction in Alzheimer's disease.Semantic proximity Read

SiGra: Single-cell spatial elucidation through image-augmented graph transformerSemantic proximity Read

SCING: Single Cell INtegrative Gene regulatory network inference elucidates robust, interpretable gene regulatory networksSemantic proximity Read

Molecular mechanism decipher of Alzheimer’s disease based on single-cell RNA-seq informationSemantic proximity Read

Single-Cell RNA-Seq Dissects the Heterogeneity of Human Microglial Related to Alzheimer’s Disease Based on Gene Regulatory NetworksSemantic proximity Read

mosGraphGen: a novel tool to generate multi-omics signaling graphs to facilitate integrative and interpretable graph AI model developmentSemantic proximity Read

Knowledge-graph-based cell-cell communication inference for spatially resolved transcriptomic data with SpaTalkSemantic proximity Read