Article

Placental defects revealed by modelling PWS in mice

2026-01-22

Abstract excerpt

The neurodevelopmental disorder Prader-Willi syndrome (PWS) is caused by loss of paternally-derived gene expression from the imprinted interval on chromosome 15q11-q13. Recently, it has been suggested that the abnormal feeding-related behaviours characteristic of PWS may, in part, be developmentally programmed in utero via abnormal placental function. Here we report that several PWS-genes are expressed in mouse p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2692a4e1-7554-5105-9c30-51aed311b960
DOI: 10.64898/2026.01.20.692090

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Placental defects revealed by modelling PWS in miceDOI 10.64898/2026.01.20.692090Read

Investigation of a Novel Mouse Model of Prader-Willi Syndrome with Invalidation of <i>Necdin</i> and <i>Magel2</i>Semantic proximity Read

Expression and imprinting of MAGEL2 suggest a role in Prader-willi syndrome and the homologous murine imprinting phenotype.Semantic proximity Read

Disruption of the mouse necdin gene results in early post-natal lethality.Semantic proximity Read

Regulation of Placental Development and Its Impact on Fetal Growth—New Insights From Mouse ModelsSemantic proximity Read

Prader-Willi syndrome transcripts are expressed in phenotypically significant regions of the developing mouse brain.Semantic proximity Read

Prader-Willi syndrome: advances in genetics, pathophysiology and treatment.Semantic proximity Read

Maternal transcription of non-protein coding RNAs from the PWS-critical region rescues growth retardation in mice.Semantic proximity Read

Placentation defects are highly prevalent in embryonic lethal mouse mutants.Semantic proximity Read

A Case of Prader-Willi Syndrome With a Deletion Including MAGEL2 , NDN , and MKRN3 , but Excluding SNRPN and SNORD116.Semantic proximity Read

Genetic abnormalities in Prader-Willi syndrome and lessons from mouse models.Semantic proximity Read

Genotype-Phenotype Relationships and Endocrine Findings in Prader-Willi SyndromeSemantic proximity Read

Fetal growth delay caused by loss of non-canonical imprinting is resolved late in pregnancy and culminates in offspring overgrowthSemantic proximity Read