Identification of a novel LysR-type transcriptional regulator in <i>Staphylococcus aureus</i> that is crucial for secondary tissue colonization during metastatic bloodstream infection

Abstract excerpt

Staphylococcus aureus is a common cause of bacteremia that can lead to severe complications once the bacteria exit the bloodstream and establish infection into secondary organs. Despite its clinical relevance, little is known about the bacterial factors facilitating the development of these metastatic infections. Here, we used a S. aureus transposon mutant library coupled to transposon insertion sequencing (Tn-Se...

Topics

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• Bacterial Proteins
• Carrier Proteins
• Cell Division
• Mice
• Mice, Inbred BALB C
• Molecular Sequence Data
• Mutagenesis
• Mutation

Identifiers and source

Literature Corpus work

a4fad163-482a-578b-b078-41f559317b50

DOI

10.1101/2020.06.23.166322