Article

Alphavirus replicons encoding IFN-γ enhance cancer virotherapy by overcoming macrophage-mediated suppression

2025-02-16

Abstract excerpt

<h4>Summary</h4> Interference by tumor-associated macrophages may significantly reduce the efficacy of therapeutic viruses designed to infect cancer cells and activate antitumor T-cells. Using a computational model, we hypothesized that viruses encoding a T cell-stimulating signal, like IFN-γ, could overcome this barrier. We engineered an alphavirus-based replicon expressing IFN-γ and evaluated its effect in vari...

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Literature Corpus work: 26709361-4eb5-5f85-8e00-8a3c2a8ddb54
DOI: 10.1101/2025.02.12.637841

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