Article
Mechanistic modeling of a novel oncolytic virus, V937, to describe viral kinetic and dynamic processes following intratumoral and intravenous administration
2024-01-30
Abstract excerpt
V937 is an investigational novel oncolytic, non-genetically modified Kuykendall strain of Coxsackievirus A21 which is in clinical development for the treatment of advanced solid tumor malignancies. V937 infects and lyses tumor cells expressing the intercellular adhesion molecule I (ICAM-I) receptor. We integrated in vitro and in vivo data from six different preclinical studies to build a mechanistic model that all...
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Identifiers and source
- Literature Corpus work
- 960652c3-dfab-596a-b78e-a10449ae1dd5
- DOI
- 10.22541/au.170665753.32137640/v1