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Engrafted Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Undergo Clonal Expansion <i>In Vivo</i>

2019-11-20

Abstract excerpt

Preclinical studies have suggested that transplanted human pluripotent stem cell-derived cardiomyocyte (hPSC-CM) grafts expand due to proliferation. This knowledge came from cell cycle activity measurements that cannot discriminate between cytokinesis or DNA synthesis associated with hypertrophy. To refine our understanding of hPSC-CM cell therapy, we genetically engineered a cardiomyocyte-specific fluorescent bar...

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Literature Corpus work
2654458a-8942-5711-889e-adead15c52a3
DOI
10.1101/847665
Open publication

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Engrafted Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Undergo Clonal Expansion <i>In Vivo</i>DOI 10.1101/847665
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